Asthma: Clinical Decision Guide is a comprehensive evidence-based handbook designed to support healthcare professionals, medical students, and advanced trainees in the recognition, diagnosis, classification, and management of asthma across diverse clinical settings. Grounded in the latest GINA 2024 recommendations, ATS/ERS standards, and current peer-reviewed literature, this guide transforms complex respiratory medicine concepts into practical clinical decision-making tools. The book systematically explores the full spectrum of asthma, beginning with epidemiology, airway inflammation, and symptom recognition before progressing into diagnostic pathways, spirometry interpretation, biomarkers, phenotypic classification, and precision medicine approaches. Special emphasis is placed on real-world clinical application, including acute exacerbation management, emergency recognition, biologic therapy selection, inhaler technique, and patient self-management strategies. Structured in a highly accessible format with tables, algorithms, risk stratification tools, and clinical pearls, the guide addresses both common and high-risk scenarios such as nocturnal asthma, cough-variant asthma, occupational asthma, exercise-induced bronchoconstriction, asthma in pregnancy, and asthma-COPD overlap. Detailed case studies further bridge the gap between theoretical knowledge and bedside clinical practice. More than a conventional textbook, Asthma: Clinical Decision Guide serves as a practical clinical companion that emphasizes early recognition, objective diagnosis, individualized treatment, and prevention of severe exacerbations. Combining scientific rigor with clinically focused clarity, this handbook is an essential resource for anyone involved in respiratory care and evidence-based asthma management.