Metabolic disorders such as obesity and diabetes are rapidly increasing worldwide and are major contributors to cardiovascular disease, including hypertension, vascular dysfunction, and diabetic cardiomyopathy. As the global burden of cardiometabolic disease continues to rise, understanding the molecular and cellular mechanisms linking metabolic dysfunction to cardiovascular injury has become increasingly important for the development of effective therapies. This volume provides a comprehensive overview of the mechanisms underlying cardiovascular dysfunction in metabolic disorders, integrating fundamental biology with translational and therapeutic perspectives. Bringing together contributions from leading investigators in the field, this book serves as a valuable resource for researchers, clinicians, and graduate students interested in cardiovascular physiology, metabolic disease, and translational medicine.