Latin America plays an important part in producing and exporting a diverse crop range. Considering the diversities of climate and ways which the crops growth in this region, they can be affected by plant pathogenic fungi causing several diseases. A management strategy of these diseases is the use of fungicides. Many fungicides have been used to control plant pathogens with multiple sprayings occurring throughout the crop growing seasons. Continued and long-term use of the same site-target fungicides associated with the occurrence of fungal pathogens with high reproductive capacity and high genetic variability lead to selection pressure for individuals and populations insensitive to these molecules. In this chapter is presented the mains problem with fungicide resistance, by the main plant pathogen fungi in Latin America, discussed the conditions that can affect this resistance, presented one typical case of resistance and strategy to management of the fungicide resistance.