Granny is at it again! When Granny accompanies her friend Mavis to the Next To The Last Resting Place nursing home to visit Mavis' sister, Beulah, both women are shocked to find the new resident dead. Granny, being the amateur detective she is, suspects foul play, and soon she and her entire family concoct a plan to investigate possible shady doings at the nursing home. Granny will enter the home incognito and attempt to determine how Beulah met her suspicious demise. All this happens while Granny's new husband Silas is entangled in his own dangerous mess. Someone has just blown up his house and Silas (a former detective) is out to discover the culprit, even as he worries about Granny's safety in the home. As more nursing home residents fall victim to a strange and sudden "memory loss virus," Granny engages the aid of her friends to get to the bottom of what turns out to be a very complex and complicated plot.