The COVID-19 pandemic was a key turning point in a culture of medical mistrust that had been building over the past thirty years in the Appalachian region. Vaccine hesitancy and a mistrust of medical experts have become increasingly common, and according to the National Institute of Health, about 25% of the American population do not find doctors and medical professionals trustworthy. Wendy Welch and Beth O'Connor focus their volume on central Appalachia and examine themes of medical mistrust among a traditionally impoverished and undereducated population with the intent of exploring historical trends, the present war on science and politicization of facts, and what rural health professionals can do to better educate and care for their patients.