S.U.G.A.R. is about the murder of quintuplets Sharon, Ursula, Gertrude, Annie, and Ruth. Their sibling rivalry and concealment of a shared dark secret come back to haunt them later. Now, in their professional careers, each is craftily eliminated. It is a classic who-done-it cast in the City of Baltimore, Maryland. The police have several suspects, including known underworld figures, that send them on a chase to France to catch the elusive and very cunning killer.