This handbook explains how to model epidemiological problems and improve inference about disease etiology from a geographical perspective. Top epidemiologists, geographers, and statisticians share interdisciplinary viewpoints on analyzing spatial data and space-time variations in disease incidences. The book explores the use of GIS and spatial statistics as tools for the analysis of spatial epidemiological data. It covers methodological advances as well as applications in human and veterinary epidemiology. A supplementary website provides color figures, program code, and datasets.