This volume provides an up-to-date survey of current laboratory and, mainly, clinical research on the diagnostic and treatment options in primary breast cancer. The chapters derive from the invited expert lectures presented at the 6th International Conference on Primary Breast Cancer held in St. Gallen, Switzerland, in February 1998. The worldwide breast cancer community has been eagerly awaiting this volume and its consensus platform and recommendations. There is no alternative to this meeting and book in the field of adjuvant therapy of primary breast cancer.