It's been two months since Dr. Janet Watson accepted an offer from Georgetown University Hospital. The training for her new high-tech arm is taking longer than expected, however, leaving her in limbo. Meanwhile, her brilliant friend and compatriot, Sara Holmes, has been placed on leave?punishment for going rogue during their previous adventure.

After an extremist faction called the Brotherhood of Redemption launches a failed assassination attempt on the president that causes mass destruction, Holmes, who is now operating in the shadows, takes on the task of investigating the Brotherhood. Holmes is making progress when she abruptly disappears.

When Watson receives a mysterious message from Holmes's cousin Micha that indicates that Sara Holmes's disappearance might be connected to the Brotherhood and to Adler Industries, Watson and Micha go on a high-stakes mission to reunite with Holmes once more.

Together, Watson, Holmes, and Micha embark on a thrilling, action-packed journey through the deep South to clear Holmes's name, thwart the Brotherhood's next move, and most important, bring their nemesis to justice for the atrocities she's committed in the New Civil War.