Two Girls and a Dead Case starts with your typical lifelong friendship of two girls who are drawn together by their similar names and then bond. After exploring what the world has in store for them they come back and open a detective agency in their small town where nothing really happens. If it wasn't for a recurring client who only seems to show up when they need the money the most they would be two broke girls with nothing better to do.

Just after they have taken another dead end case from this client they receive a mysterious box which leads them to a case that is more interesting but far more dangerous than anything they have ever done. And just as one of the girls thinks that the case is solved something happens that will change everything for not only the girls but for everyone that loves them as well.