Set in New York, in 1956, Matsos and Meatballs: A Love Story? tells the story of the Sappertein sisters and traces their path from birth to their eighteenth year, which is when the trouble begins.

Though the girls are twins, their personalities couldn't be more different. Through the words of the younger twin, Jill, we are introduced to the Sapperstein family, consisting of: father, Sheldon, who insists that one of his daughters was born with a head slightly larger than her sibling; his wife, Thelma, sister Joan and the girls' Bubbe, who well may have a heart attack after learning that the girls have fallen for a young, handsome, soldier, Michael Calavito, who is decidedly not Jewish.

The girls vie for the affections of the young Italian in a classic case of sibling rivalry, much to the chagrin of both families.

While the adults lament the fact that the two cultures have unsurmountable differences. In fact, if anything, the two families are more similar that they might think.