The basic science of the cellular and molecular responses of the brain to injury is a rapidly expanding area of research that provides evidence of growing opportunities for pharmacological intervention in the clinic

Featuring up-to-date reviews of the most important areas of study regarding cellular and molecular responses of the brain to injury, this book introduces the problem of CNS damage at the cellular, immune, and vascular levels. CNS Injuries: Cellular Responses and Pharmacological Strategies discusses possible therapeutic strategies for manipulating major events in the injury response, including: inflammatory and immune reactions; scarring; neuron death; demylenation and remyelination; axonal regeneration; reestablishment of neuronal connectivity. This enlightening reference is sure to benefit researchers and practitioners in a broad range of disciplines, including pharmacology, pathology, toxicology and many others. TOC:Cellular Responses to Penetrating CNS Injury. - Cellular Responses to Ischaemic CNS Injury. - The Immune Response and CNS Injury. - Haematogenous Cell Responses to CNS Injury. Role of Macrophages and Microglia in the Injured CNS. - Cellular Trafficking. Protease Inhibitors and Microglia/Macrophage-Modulating Drugs Prevent Microglia-Mediated Neuronal Death in the Traumatized and Dystrophic Retina. Transforming Growth Factor-b and CNS Scarring. Neurotrophic Factors. Fibroblast Growth Factors. Index.