Presents various approaches in the implementation of combinatorial research methodologies for the synthesis of natural product-based libraries. This volume describes strategies and designs for successful synthesis, summarizing the challenges and opportunities in the combinatorial organic synthesis of natural product-based libraries.
Combinatorial Synthesis of Natural Product-Based Libraries presents the latest approaches in the implementation of combinatorial research methodologies for the synthesis of natural product-based libraries. It describes strategies and designs for successful synthesis, summarizing the challenges and opportunities in the combinatorial organic synthesis of natural product-based libraries. It also examines how to improve efficiency of combinatorial screening by using natural products in the design of screening compounds. Highlighting new developments in synthetic, organic, and combinatorial chemistry, this text serves combinatorial and medicinal chemists as well as natural products scientists.
"[This book] elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the historical developments to the latest technologies, from the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ...A huge amount of references give the readers the opportunity to return to the original papers... ... A large amount of appealing Figures and Schemes illustrate the concepts discussed in the text. The Chapters are well structured... As the authors are from different backgrounds, the book covers various strategies, various synthetic methods, and all types of compound families. ...[A] valuable tool for everybody working in medicinal chemistry as well as the agrochemical, industrial, or academic domains.
- François Diederich, Swiss Federal Institute of Technology, Zurich
"...Elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ..."
- François Diederich, Swiss Federal Institute of Technology, Zurich
"A first-rate source of information to learn about different planning strategies"
-Victor E. Marquez in Journal of Medicinal Chemistry 2007, Vol. 50, No. 5 (2007)
